KNOWLISESDEGNE PREVENTIA® Surgical Irrigation Prevention of biofilms in surgery Dissolving a biofilm requires a combination of the mechanical power of irrigation fluid itself and ingredients that support it [4]. Current studies confirm the efficacy of PREVENTIA® Surgical Irrigation against biofilms and planktonic cells as well as its tolerability for human cells and tissue [4-6]. This irrigation solution consists of the active ingredient polyhexanide (PHMB) and the surfactant poloxamer. While PHMB has long been known for its antimicrobial activity, the novel combination allows it to reach the site of action more efficiently [7]. PREVENTIA® can be used, for example, for orthopaedic procedures and in the wound closure phase in general. PREVENTIA® Surgical Irrigation is effective in higher dilutions than PVP iodine The in vitro study by Dudek et al. [4] investigated the efficacy of various antiseptic and rinsing solutions against several hospital germs. For example, PREVENTIA® effectively killed all pathogens even when tested in higher dilutions than PVP iodine. In addition, cytotoxicity was investigated in an alternative in vivo model using caterpillars. Interestingly, only PVP iodine caused noticeable damage to the animals tested. [4]. Biofilms pose a major challenge in surgery. The shielded environment that a biofilm offers microorganisms protects them from external influences and can favour the development of antibiotic-resistant germs [1]. Surgical site infections account for around 16% of all nosocomial infections in Europe [2] and 80% are attributable to biofilms [3]. Complete inactivation within one minute Watson et al. [5] confirmed the efficacy of PREVENTIA® in the timekill assay: among others, PREVENTIA® completely inactivated all cultures within one minute. The therapeutic index (ratio between required active concentration and toxicity on mammalian cells) was also most favorable for PREVENTIA® compared to PVP iodine and others [5]. Finally, the efficacy of PREVENTIA® was demonstrated in a third in vitro study in which all but one of the solutions met the requirements for bactericidal activity, while toxicity was not part of the study [6]. Conclusion Efficacy and tolerability must always be carefully weighed up against each other. PREVENTIA® Surgical Irrigation proved to be effective overall against biofilms and planktonic cells – while at the same time being very well tolerated. With PREVENTIA®, HARTMANN is making a further contribution to the Mission: Infection Prevention (M: IP®) Figure based on data from [4]. MBEC = minimal biofilm eradication concentration. Concentration of PHMB in combination with macrogol lower than in PREVENTIA® (0.04% vs. 0.1%). * = none of the tested dilutions was sufficient to inactivate the biofilm. Figure modified after [5]. Time-kill assay, here exemplified for P. aeruginosa. CFU = colony forming units. Concentration of PHMB in combination with macrogol lower than in PREVENTIA® (0.04% vs. 0.1%). References 1. Sahoo K, Meshram S (2024) Cureus 16: e70629. https://doi.org/10.7759/cureus.70629 2. European Center for Disease Prevention and Control. Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals. Stockholm: ECDC; 2024. https://www.ecdc.europa.eu/sites/default/files/documents/healthcare-associated-point-prevalence-survey-acute-carehospitals-2022-2023.pdf (accessed on 27.02.2025) 3. Hrynyshyn A et al. (2022) Antibiotics (Basel) 11: 69. https://doi.org/10.3390/antibiotics11010069 4. Dudek B et al. (2024) Int J Mol Sci 25: 12720. https://doi.org/10.3390/ijms252312720 5. Watson F et al. (2014) GMS Hyg Infect Control 19: Doc73. https://doi.org/10.3205/dgkh000528 6. Honegger AL et al. (2025) Antibiotics (Basel) 14: 25. https://doi.org/10.3390/antibiotics14010025 7. https://www.hartmann.info/de-de/themen/surgical-site-infection/preventia (accessed on 27.02.2025) 15
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